Literature summary extracted from
Collins, G.T.; Brim, R.L.; Narasimhan, D.; Ko, M.C.; Sunahara, R.K.
Zhan. C.G.; Woods. J.H.: Cocaine esterase prevents cocaine-induced toxicity and the ongoing intravenous self-administration of cocaine in rats (2009), J. Pharmacol. Exp. Ther., 331, 445-455.
Application
EC Number |
Application |
Comment |
Organism |
---|
3.1.1.84 |
medicine |
a series of experiments demonstrates the capacity of the longer acting mutant, CocE T172R/G173Q, to provide a long-lasting protection against cocaine-induced convulsion and lethality, and a dose-dependent and selective inhibition the ongoing self-administration of cocaine in rats. Potential usefulness of a suitable, stable, and long-acting form of CocE as a pharmacotherapy for cocaine abuse in humans |
Rhodococcus sp. |
Protein Variants
EC Number |
Protein Variants |
Comment |
Organism |
---|
3.1.1.84 |
T172R/G173Q |
mutant enzyme with increased half-life |
Rhodococcus sp. |
Organism
EC Number |
Organism |
UniProt |
Comment |
Textmining |
---|
3.1.1.84 |
Rhodococcus sp. |
Q9L9D7 |
- |
- |
Synonyms
EC Number |
Synonyms |
Comment |
Organism |
---|
3.1.1.84 |
cocE |
- |
Rhodococcus sp. |